Across TCGA pan-cancer cohorts, SH3BGRL2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SH3BGRL2 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SH3BGRL2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SH3BGRL2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where SH3BGRL2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.489	0.276	.009	16	view →
CCRCC	OS	Tertile	All	1.000	0.888	.014	10	view →
UCEC	DFS	Median	All	0.933	0.783	.022	8	view →
LUAD	DFS	Tertile	II,III,IV	0.716	0.991	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SH3BGRL2 tumor-vs-normal RNA expression · all SH3BGRL2 data types