Across TCGA cell cohorts, SH3BGRL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,193 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SH3BGRL2-associated GO terms across cancer lineages are Negative regulation of stem cell differentiation, Membrane fission, and Neutrophil activation. Each is linked with SH3BGRL2 in more than 10 cancer types. Because this analysis shows association rather than direction, both SH3BGRL2-to-partner and partner-to-SH3BGRL2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGRL2→partner) and Y-score (partner→SH3BGRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of stem cell differentiation →	+0.159	+1.279	<.001	<.001	3	11
URINARY_TRACT	Membrane fission →	+0.059	+1.189	<.001	.003	3	10
STOMACH	Neutrophil activation →	+0.163	+1.904	.002	.001	3	9
KIDNEY	Regulation of syncytium formation by plasma membrane fusion →	+0.092	+1.515	.001	.001	3	9
LARGE_INTESTINE	Regulation of endoplasmic reticulum unfolded protein response →	+0.052	+0.938	.001	.002	3	9
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.220	-1.864	.003	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,193 associations by consensus.

Exploration

SH3BGRL2 survival (RNA) · tumor vs normal (RNA) · all SH3BGRL2 data types