SH3BGRL

Across TCGA pan-cancer cohorts, SH3BGRL mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SH3BGRL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SH3BGRL mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SH3BGRL is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where SH3BGRL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SH3BGRL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.402	<.001	11	view →
COAD	Male	III,IV	−1.476	<.001	10	view →
LUAD	Male	III,IV	−0.433	<.001	9	view →
LSCC	Male	II,III,IV	−0.776	<.001	8	view →
PDAC	Female	All	+0.442	<.001	5	view →
CCRCC	All	All	+0.139	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SH3BGRL–HNSC

Open the HNSC breakdown →