Across TCGA pan-cancer cohorts, SH3BGR Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SH3BGR data layer compared with 25 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SH3BGR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SH3BGR expression acts as an unfavorable survival marker.

UCEC, LIHC, and COAD are the cancer types where SH3BGR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	OS	Median	All	0.258	0.773	.018	6	view →
COAD	OS	Median	All	0.556	0.870	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SH3BGR tumor-vs-normal RNA expression · all SH3BGR data types