SH3BGR

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SH3BGR mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BGR-associated genes across cancer lineages are LINC02703, GTF3AP2, and CHAF1A. Each is linked with SH3BGR in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BGR-to-partner and partner-to-SH3BGR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGR→partner) and Y-score (partner→SH3BGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMLINC02703 →+0.278+4.263<.001<.00132
LUSCGTF3AP2 →+0.251+4.150<.001.00332
UCECCHAF1A →+0.638+3.807.002<.00132
UCECCTU2 →+0.550+2.818<.001.00132
UCECCAPZB →+0.447+3.939<.001<.00132
UCECITGAE →+0.420+3.191.004.00932
Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

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