Across TCGA patient cohorts, SH3BGR mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH3BGR-associated genes across cancer lineages are A-Raf_pS299, SLC1A5, and STAT3_pY705. Each is linked with SH3BGR in more than 1 cancer types. Because this analysis shows association rather than direction, both SH3BGR-to-partner and partner-to-SH3BGR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH3BGR→partner) and Y-score (partner→SH3BGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.129	-3.169	.025	.019	3	1
UCEC	SLC1A5 →	+0.488	+3.169	.022	.019	3	1
UCEC	STAT3_pY705 →	-0.379	-2.459	.002	.020	3	1
UCEC	ASNS →	+0.508	+3.169	.003	.019	3	1
UCEC	MEK1 →	+0.533	+3.584	.002	.002	2	1
UCEC	p62 Lck ligand →	+0.358	+2.817	.023	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

SH3BGR survival (RNA) · tumor vs normal (RNA) · all SH3BGR data types