Across TCGA patient cohorts, SH2D7 mutation is significantly associated with the RNA expression of many other genes, with 1,447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D7-associated genes across cancer lineages are UBAP1, ATP5MG, and TMEM38B. Each is linked with SH2D7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D7-to-partner and partner-to-SH2D7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D7→partner) and Y-score (partner→SH2D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBAP1 →	+0.430	+3.459	.001	.005	3	2
UCEC	ATP5MG →	+0.324	+2.338	.001	.003	3	2
UCEC	TMEM38B →	+0.751	+2.436	<.001	.001	3	2
UCEC	BAG1 →	+0.617	+2.070	<.001	.001	3	2
UCEC	ITGB1BP1 →	+0.360	+2.518	.001	.001	3	2
UCEC	CKS2 →	+0.593	+1.931	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,447 associations by consensus.

Exploration

SH2D7 survival (RNA) · tumor vs normal (RNA) · all SH2D7 data types