Across TCGA patient cohorts, SH2D7 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D7-associated genes across cancer lineages are Caspase-8, JNK2, and MEK1. Each is linked with SH2D7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D7-to-partner and partner-to-SH2D7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D7→partner) and Y-score (partner→SH2D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.249	-1.973	.011	.029	3	2
UCEC	JNK2 →	+0.252	+3.026	.001	.018	3	1
UCEC	MEK1 →	+0.311	+1.807	.030	.025	3	1
UCEC	Notch1 →	+0.145	+1.584	.008	.036	3	1
UCEC	p62 Lck ligand →	+0.454	+3.584	<.001	.002	3	1
UCEC	PCNA →	+0.221	+2.000	.009	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

SH2D7 survival (RNA) · tumor vs normal (RNA) · all SH2D7 data types