Across TCGA cell cohorts, SH2D7 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2D7-associated genes across cancer lineages are FAM71A, HSFY2, and HMX3. Each is linked with SH2D7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D7-to-partner and partner-to-SH2D7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D7→partner) and Y-score (partner→SH2D7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71A →	+0.043	+2.938	.006	.003	3	1
LARGE_INTESTINE	HSFY2 →	+0.008	+2.977	<.001	.006	3	1
LARGE_INTESTINE	HMX3 →	+0.426	+3.302	.005	.008	3	1
LARGE_INTESTINE	MAGEB1 →	+0.123	+2.556	.008	.006	3	1
LARGE_INTESTINE	CD300H →	+0.024	+3.415	<.001	.001	3	1
BLOOD_Leukemia	TCF21 →	+0.019	+4.705	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

SH2D7 survival (RNA) · tumor vs normal (RNA) · all SH2D7 data types