Across TCGA patient cohorts, SH2D5 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,848 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SH2D5-associated proteins across cancer lineages are SH2D5_S231, MACF1_S4496, and MAP4_S696. Each is linked with SH2D5 in more than 5 cancer types. Because this analysis shows association rather than direction, both SH2D5-to-partner and partner-to-SH2D5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D5→partner) and Y-score (partner→SH2D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH2D5_S231 →	+1.596	+1.213	<.001	<.001	3	6
HNSC	MACF1_S4496 →	+0.734	+1.451	<.001	<.001	3	6
LUAD	MAP4_S696 →	+0.656	+0.165	.001	.005	3	6
CCRCC	PSMB10 →	-0.406	-0.679	<.001	<.001	3	5
PDAC	PARD3B_S710 →	-0.499	-0.312	<.001	<.001	3	5
BRCA	ANLN →	+0.740	+0.236	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,848 associations by consensus.

Exploration

SH2D5 survival (RNA) · tumor vs normal (RNA) · all SH2D5 data types