Across TCGA patient cohorts, SH2D5 protein abundance is significantly associated with the RNA expression of many other genes, with 2,092 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SH2D5-associated genes across cancer lineages are EZH2, ALDH6A1, and TAS2R4. Each is linked with SH2D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D5-to-partner and partner-to-SH2D5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D5→partner) and Y-score (partner→SH2D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EZH2 →	-0.810	-0.790	.002	.004	3	1
HNSC	ALDH6A1 →	-1.027	-0.713	<.001	.002	3	1
HNSC	TAS2R4 →	-1.288	-0.713	<.001	.002	3	1
HNSC	OSTF1 →	-0.654	-0.720	.001	.001	3	1
HNSC	C1orf56 →	-0.573	-0.713	.001	.002	3	1
HNSC	UBN2 →	-0.718	-0.713	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,092 associations by consensus.

Exploration

SH2D5 survival (RNA) · tumor vs normal (RNA) · all SH2D5 data types