SH2D5

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SH2D5 mutation is significantly associated with the RNA expression of many other genes, with 1,819 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D5-associated genes across cancer lineages are MIR6839, WASF1P1, and UFL1-AS1. Each is linked with SH2D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D5-to-partner and partner-to-SH2D5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D5→partner) and Y-score (partner→SH2D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECMIR6839 →+0.200+2.492<.001.00832
CESCWASF1P1 →+0.113+5.010<.001.00932
COADUFL1-AS1 →+0.394+3.845<.001.00332
COADRPL23AP69 →+0.180+4.001.009.00232
COADRN7SL83P →+0.323+4.070<.001.00932
SKCMH2AB3 →+0.054+6.495<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,819 associations by consensus.

Exploration