Across TCGA patient cohorts, SH2D5 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D5-associated genes across cancer lineages are Lck, ATM, and EGFR_pY1068. Each is linked with SH2D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D5-to-partner and partner-to-SH2D5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D5→partner) and Y-score (partner→SH2D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.206	+2.000	.022	.032	3	2
UCEC	ATM →	-0.437	-2.700	.032	.006	3	2
UCEC	EGFR_pY1068 →	-0.409	-3.807	<.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.207	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.262	+3.807	.002	<.001	3	1
UCEC	ACC1 →	+0.405	+3.013	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

SH2D5 survival (RNA) · tumor vs normal (RNA) · all SH2D5 data types