Across TCGA cell cohorts, SH2D5 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2D5-associated genes across cancer lineages are GP2, LCE1F, and IL17F. Each is linked with SH2D5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D5-to-partner and partner-to-SH2D5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D5→partner) and Y-score (partner→SH2D5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GP2 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	LCE1F →	+0.166	+4.807	<.001	.006	3	1
LARGE_INTESTINE	IL17F →	+0.047	+3.252	<.001	<.001	3	1
LARGE_INTESTINE	CLEC18C →	+0.133	+3.240	.002	.007	3	1
LARGE_INTESTINE	SLAMF8 →	+0.085	+2.869	.003	.008	3	1
LARGE_INTESTINE	PRKACG →	+0.019	+2.736	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

SH2D5 survival (RNA) · tumor vs normal (RNA) · all SH2D5 data types