SH2D4A

Across TCGA pan-cancer cohorts, SH2D4A Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SH2D4A data layer compared with 28 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SH2D4A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SH2D4A expression acts as an unfavorable survival marker.

HNSC, LIHC, and BLCA are the cancer types where SH2D4A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.138	0.743	<.001	42	view →
LIHC	OS	Median	All	0.179	0.779	<.001	27	view →
BLCA	OS	Median	III,IV	0.051	0.684	<.001	18	view →
LUAD	OS	Median	All	0.323	0.834	.006	12	view →
READ	DFS	Median	II,III,IV	0.112	0.800	.002	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
CESC	OS	Median	II,III,IV	0.125	0.547	.047	4	view →
GBM	OS	Median	All	0.121	0.415	.042	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SH2D4A–HNSC (OS)

Open the HNSC breakdown →