SH2D4A

Across TCGA pan-cancer cohorts, SH2D4A mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SH2D4A data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SH2D4A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SH2D4A expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and UCEC are the cancer types where SH2D4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.944	0.792	.001	44	view →
COAD	DFS	Median	All	1.000	0.891	.027	18	view →
UCEC	DFS	Quartile	All	0.954	0.757	.017	12	view →
OV	DFS	Tertile	All	0.923	0.473	.036	8	view →
LSCC	OS	Median	All	0.922	1.000	.010	4	view →
GBM	OS	Median	All	0.647	0.867	.021	3	view →
LUAD	OS	Median	II,III,IV	0.978	0.884	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SH2D4A–PDAC (OS)

Open the PDAC breakdown →