SH2D4A

Across TCGA patient cohorts, SH2D4A RNA expression is significantly associated with the protein abundance of many other proteins, with 11,668 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SH2D4A-associated proteins across cancer lineages are SH2D4A_S261, MTUS1, and SH2D4A_S315. Each is linked with SH2D4A in more than 8 cancer types. Because this analysis shows association rather than direction, both SH2D4A-to-partner and partner-to-SH2D4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2D4A versus SH2D4A_S261 in LUAD, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4A→partner) and Y-score (partner→SH2D4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SH2D4A_S261 →	+1.031	+0.745	<.001	<.001	3	9
COAD	MTUS1 →	+0.711	+0.802	<.001	<.001	3	8
PDAC	SH2D4A_S315 →	+1.232	+0.946	<.001	<.001	3	8
COAD	ERI1 →	+0.437	+0.810	<.001	<.001	3	8
LSCC	GSR →	+0.563	+0.748	<.001	<.001	3	8
BRCA	KIF13B →	+0.522	+0.790	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,668 associations by consensus.

SH2D4A vs SH2D4A_S261 — LUAD

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