SH2D4A

Across TCGA patient cohorts, SH2D4A protein abundance is significantly associated with the RNA expression of many other genes, with 10,596 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SH2D4A-associated genes across cancer lineages are FDFT1, INTS10, and DCTN6. Each is linked with SH2D4A in more than 7 cancer types. Because this analysis shows association rather than direction, both SH2D4A-to-partner and partner-to-SH2D4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SH2D4A versus FDFT1 in COAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4A→partner) and Y-score (partner→SH2D4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FDFT1 →	+1.019	+0.429	<.001	<.001	3	8
UCEC	INTS10 →	+0.771	+0.647	<.001	<.001	3	7
BRCA	DCTN6 →	+0.559	+0.419	.002	.002	3	7
COAD	PPP2CB →	+0.628	+0.482	<.001	<.001	3	7
HNSC	PPP2R2A →	+0.518	+0.524	<.001	<.001	3	7
COAD	SARAF →	+0.722	+0.509	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,596 associations by consensus.

SH2D4A vs FDFT1 — COAD

Explore this scatter interactively →