SH2D4A

Across TCGA patient cohorts, SH2D4A mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D4A-associated genes across cancer lineages are Di-Ras3, 14-3-3_beta, and EGFR_pY1068. Each is linked with SH2D4A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D4A-to-partner and partner-to-SH2D4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by SH2D4A-low versus SH2D4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4A→partner) and Y-score (partner→SH2D4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.167	-3.446	.006	.005	3	2
UCEC	14-3-3_beta →	-0.091	-2.973	.027	.035	3	1
UCEC	EGFR_pY1068 →	-0.222	-1.807	.032	.027	3	1
UCEC	A-Raf_pS299 →	-0.104	-3.169	.035	.019	3	1
UCEC	FoxM1 →	+0.213	+2.321	.046	.006	3	1
UCEC	JNK2 →	+0.277	+1.807	<.001	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Di-Ras3 by SH2D4A expression — UCEC

Explore this box plot interactively →