SH2D4A

Across TCGA cell cohorts, SH2D4A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,731 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SH2D4A-associated GO terms across cancer lineages are Membrane biogenesis, Actin filament organization, and Cellular response to environmental stimulus. Each is linked with SH2D4A in more than 10 cancer types. Because this analysis shows association rather than direction, both SH2D4A-to-partner and partner-to-SH2D4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane biogenesis grouped by SH2D4A-low versus SH2D4A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4A→partner) and Y-score (partner→SH2D4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Membrane biogenesis →	+0.092	+3.050	<.001	<.001	3	11
BONE	Actin filament organization →	+0.102	+2.645	<.001	<.001	3	11
SOFT_TISSUE	Cellular response to environmental stimulus →	+0.050	+2.075	<.001	<.001	3	11
BONE	Small GTPase-mediated signal transduction →	+0.061	+2.399	.002	.002	3	11
SOFT_TISSUE	Cellular response to abiotic stimulus →	+0.050	+2.075	<.001	<.001	3	11
SKIN	Regulation of endothelial tube morphogenesis →	+0.947	+1.765	<.001	.003	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,731 associations by consensus.

Membrane biogenesis by SH2D4A expression — BONE

Explore this box plot interactively →