SH2D4A

Across TCGA cell cohorts, SH2D4A mutation is significantly associated with the drug of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SH2D4A-associated genes across cancer lineages are LCL161, Fludarabine, and 123829. Each is linked with SH2D4A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D4A-to-partner and partner-to-SH2D4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCL161 grouped by SH2D4A-low versus SH2D4A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D4A→partner) and Y-score (partner→SH2D4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LCL161 →	+0.419	+2.646	.009	.047	3	1
LARGE_INTESTINE	Fludarabine →	+0.571	+2.649	.031	.046	3	1
LARGE_INTESTINE	123829 →	+0.664	+2.649	.022	.046	3	1
LARGE_INTESTINE	50869 →	+0.421	+2.649	.047	.046	3	1
LARGE_INTESTINE	CZC24832 →	+0.270	+2.646	.038	.047	2	1
LARGE_INTESTINE	Entospletinib →	+0.425	+2.646	.026	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LCL161 by SH2D4A expression — LARGE_INTESTINE

Explore this box plot interactively →