Across TCGA patient cohorts, SH2D1B RNA expression is significantly associated with the protein abundance of many other proteins, with 7,364 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SH2D1B-associated proteins across cancer lineages are GIMAP7, STAT1, and GBP5. Each is linked with SH2D1B in more than 7 cancer types. Because this analysis shows association rather than direction, both SH2D1B-to-partner and partner-to-SH2D1B results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1B→partner) and Y-score (partner→SH2D1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GIMAP7 →	+0.644	+0.474	<.001	<.001	3	8
COAD	STAT1 →	+0.615	+0.582	<.001	<.001	3	7
BRCA	GBP5 →	+0.842	+0.355	<.001	<.001	3	7
HNSC	GIMAP8 →	+0.619	+0.825	<.001	<.001	3	7
HNSC	LCP2 →	+0.569	+0.848	<.001	.001	3	6
OV	ARHGAP25 →	+1.457	+0.937	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,364 associations by consensus.

Exploration

SH2D1B survival (RNA) · tumor vs normal (RNA) · all SH2D1B data types