Across TCGA patient cohorts, SH2D1B protein abundance is significantly associated with the RNA expression of many other genes, with 229 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SH2D1B-associated genes across cancer lineages are ZNF157, ZNF18, and S100G. Each is linked with SH2D1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D1B-to-partner and partner-to-SH2D1B results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1B→partner) and Y-score (partner→SH2D1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZNF157 →	-0.420	-1.270	.008	.001	3	1
LSCC	ZNF18 →	-0.565	-1.295	.002	.002	3	1
LSCC	S100G →	-0.999	-1.270	.008	.001	3	1
LSCC	FABP5P10 →	-0.356	-1.441	<.001	.003	3	1
LSCC	RBM39P1 →	-0.333	-1.374	.001	<.001	3	1
LSCC	RPL6P5 →	-0.186	-1.319	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 229 associations by consensus.

Exploration

SH2D1B survival (RNA) · tumor vs normal (RNA) · all SH2D1B data types