Across TCGA patient cohorts, SH2D1B mutation is significantly associated with the RNA expression of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D1B-associated genes across cancer lineages are COX5AP2, RNU6-1150P, and ZACNP1. Each is linked with SH2D1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D1B-to-partner and partner-to-SH2D1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1B→partner) and Y-score (partner→SH2D1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	COX5AP2 →	+0.294	+3.788	<.001	.005	3	2
LUSC	RNU6-1150P →	+0.589	+5.151	<.001	.007	3	2
LUSC	ZACNP1 →	+0.339	+5.337	<.001	.006	3	2
SKCM	MIR3944 →	+0.319	+2.617	.003	.005	3	2
PRAD	RNU6-1031P →	+0.288	+7.939	<.001	.008	3	1
LUAD	C10orf126 →	+0.393	+3.943	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

SH2D1B survival (RNA) · tumor vs normal (RNA) · all SH2D1B data types