Across TCGA patient cohorts, SH2D1B mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible SH2D1B-associated genes across cancer lineages are CMP, Erythrocytes, and CD8+ T-cells. Each is linked with SH2D1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D1B-to-partner and partner-to-SH2D1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1B→partner) and Y-score (partner→SH2D1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CMP →	+0.032	+2.577	<.001	.037	3	1
LUAD	Erythrocytes →	+0.021	+3.513	.016	.011	3	1
UCEC	CD8+ T-cells →	+0.017	+3.108	.021	.011	3	1
SKCM	Th2 cells →	+0.230	+3.176	.013	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

SH2D1B survival (RNA) · tumor vs normal (RNA) · all SH2D1B data types