Across TCGA pan-cancer cohorts, SH2D1A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SH2D1A data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SH2D1A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SH2D1A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, UCEC, and BLCA are the cancer types where SH2D1A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.227	0.798	.002	18	view →
UCEC	DFS	Median	All	1.000	0.827	.009	12	view →
BLCA	OS	Median	All	0.249	0.709	.042	6	view →
SKCM	DFS	Median	III,IV	0.212	0.617	.011	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SH2D1A tumor-vs-normal RNA expression · all SH2D1A data types