Across TCGA patient cohorts, SH2D1A RNA expression is significantly associated with the protein abundance of many other proteins, with 17,225 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2D1A-associated proteins across cancer lineages are RASAL3, ARHGAP45, and ARHGDIB. Each is linked with SH2D1A in more than 9 cancer types. Because this analysis shows association rather than direction, both SH2D1A-to-partner and partner-to-SH2D1A results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1A→partner) and Y-score (partner→SH2D1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RASAL3 →	+0.635	+0.978	<.001	<.001	3	10
OV	ARHGAP45 →	+0.648	+1.151	<.001	<.001	3	10
OV	ARHGDIB →	+0.784	+1.085	<.001	<.001	3	10
HNSC	PSMB10 →	+0.581	+1.227	<.001	<.001	3	10
CCRCC	ADA2 →	+0.641	+0.877	<.001	<.001	3	10
OV	CASP1 →	+0.613	+0.714	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,225 associations by consensus.

Exploration

SH2D1A survival (RNA) · tumor vs normal (RNA) · all SH2D1A data types