Across TCGA patient cohorts, SH2D1A protein abundance is significantly associated with the RNA expression of many other genes, with 13,209 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SH2D1A-associated genes across cancer lineages are CCL19, TRAJ31, and TNFRSF17. Each is linked with SH2D1A in more than 8 cancer types. Because this analysis shows association rather than direction, both SH2D1A-to-partner and partner-to-SH2D1A results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1A→partner) and Y-score (partner→SH2D1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCL19 →	+4.082	+1.764	.004	.005	3	9
GBM	TRAJ31 →	+3.147	+2.022	<.001	.006	3	9
OV	TNFRSF17 →	+1.814	+1.451	.002	<.001	3	8
GBM	CD2 →	+2.726	+2.022	.008	.006	3	8
LSCC	LY9 →	+0.955	+0.854	<.001	<.001	3	8
HNSC	ZNF831 →	+1.063	+0.955	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,209 associations by consensus.

Exploration

SH2D1A survival (RNA) · tumor vs normal (RNA) · all SH2D1A data types