Across TCGA patient cohorts, SH2D1A mutation is significantly associated with the RNA expression of many other genes, with 1,985 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D1A-associated genes across cancer lineages are SLC6A14P3, OR51L1, and OR2G2. Each is linked with SH2D1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D1A-to-partner and partner-to-SH2D1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1A→partner) and Y-score (partner→SH2D1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC6A14P3 →	+0.104	+5.279	.004	.006	3	2
HNSC	OR51L1 →	+0.131	+6.763	<.001	<.001	3	2
HNSC	OR2G2 →	+0.122	+5.182	<.001	.007	3	2
HNSC	OR51D1 →	+0.052	+5.368	<.001	.005	3	2
UCEC	RNU6-222P →	+0.344	+1.783	<.001	.008	3	2
UCEC	IGHD2-2 →	+0.969	+1.872	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,985 associations by consensus.

Exploration

SH2D1A survival (RNA) · tumor vs normal (RNA) · all SH2D1A data types