Across TCGA patient cohorts, SH2D1A mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SH2D1A-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Ku80. Each is linked with SH2D1A in more than 1 cancer types. Because this analysis shows association rather than direction, both SH2D1A-to-partner and partner-to-SH2D1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SH2D1A→partner) and Y-score (partner→SH2D1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.265	-2.736	.004	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.170	-2.415	.006	.003	3	1
UCEC	Ku80 →	+0.219	+1.515	.011	.018	3	1
UCEC	p21 →	+0.167	+3.183	.018	.009	3	1
UCEC	p53 →	-0.306	-2.321	.031	.033	3	1
UCEC	p62 Lck ligand →	+0.320	+2.247	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

SH2D1A survival (RNA) · tumor vs normal (RNA) · all SH2D1A data types