Across TCGA patient cohorts, SGTB mutation is significantly associated with the RNA expression of many other genes, with 910 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGTB-associated genes across cancer lineages are RNU6-1137P, VN1R46P, and INTS4. Each is linked with SGTB in more than 1 cancer types. Because this analysis shows association rather than direction, both SGTB-to-partner and partner-to-SGTB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGTB→partner) and Y-score (partner→SGTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-1137P →	+0.294	+4.384	<.001	.008	3	2
CESC	VN1R46P →	+0.043	+4.757	<.001	.004	3	2
UCEC	INTS4 →	+0.374	+3.332	.006	.005	3	1
UCEC	CHEK1 →	+0.896	+3.480	<.001	.002	3	1
UCEC	DSN1 →	+0.628	+3.592	.004	.001	3	1
UCEC	ALDOA →	+0.623	+3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 910 associations by consensus.

Exploration

SGTB survival (RNA) · tumor vs normal (RNA) · all SGTB data types