Across TCGA patient cohorts, SGTB mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGTB-associated genes across cancer lineages are ACVRL1, Myosin-IIa, and p70-S6K_pT389. Each is linked with SGTB in more than 1 cancer types. Because this analysis shows association rather than direction, both SGTB-to-partner and partner-to-SGTB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGTB→partner) and Y-score (partner→SGTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.155	-2.439	.014	.019	3	1
UCEC	Myosin-IIa →	+0.270	+2.466	.002	.011	3	1
UCEC	p70-S6K_pT389 →	-0.258	-2.584	.003	.011	3	1
UCEC	PCNA →	+0.394	+3.321	<.001	.010	3	1
UCEC	PDCD4 →	-0.548	-2.312	.012	.034	3	1
UCEC	Rab11 →	-0.136	-2.980	.044	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

SGTB survival (RNA) · tumor vs normal (RNA) · all SGTB data types