SGTA

Across TCGA pan-cancer cohorts, SGTA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SGTA data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SGTA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SGTA expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where SGTA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	III,IV	1.000	0.433	.007	28	view →
LSCC	DFS	Median	II,III,IV	1.000	0.834	.005	23	view →
LUAD	OS	Median	All	0.765	0.903	.013	8	view →
GBM	OS	Quartile	All	0.948	0.721	.025	2	view →
HNSC	DFS	Tertile	IV	0.498	0.795	.017	2	view →
PDAC	DFS	Median	II,III,IV	0.465	0.324	.021	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SGTA–UCEC (OS)

Open the UCEC breakdown →