SGTA

Across TCGA pan-cancer cohorts, SGTA mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SGTA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SGTA mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SGTA is over-expressed in tumor.

LUAD, LSCC, and COAD are the cancer types where SGTA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SGTA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+0.479	<.001	9	view →
LSCC	Male	All	+0.456	<.001	8	view →
COAD	Male	All	+0.208	<.001	8	view →
HNSC	All	III,IV	+0.202	<.001	7	view →
PDAC	All	II,III,IV	+0.202	.004	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SGTA–LUAD

Open the LUAD breakdown →