SGTA

Across TCGA patient cohorts, SGTA mutation is significantly associated with the RNA expression of many other genes, with 1,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGTA-associated genes across cancer lineages are RNA5SP158, RPL34P8, and RPS29P32. Each is linked with SGTA in more than 1 cancer types. Because this analysis shows association rather than direction, both SGTA-to-partner and partner-to-SGTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP158 grouped by SGTA-low versus SGTA-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGTA→partner) and Y-score (partner→SGTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP158 →	+0.231	+4.636	<.001	.006	3	2
UCEC	RPL34P8 →	+0.367	+2.069	<.001	.004	3	2
COAD	RPS29P32 →	+0.462	+4.251	<.001	.008	3	2
UCEC	RNA5SP378 →	+0.553	+2.223	<.001	.002	3	2
UCEC	RNU6-440P →	+0.181	+3.827	<.001	.001	3	2
UCEC	RNU6ATAC30P →	+0.512	+2.347	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,659 associations by consensus.

RNA5SP158 by SGTA expression — HNSC

Explore this box plot interactively →