SGTA

Across TCGA patient cohorts, SGTA mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGTA-associated genes across cancer lineages are Stathmin, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with SGTA in more than 1 cancer types. Because this analysis shows association rather than direction, both SGTA-to-partner and partner-to-SGTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by SGTA-low versus SGTA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGTA→partner) and Y-score (partner→SGTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.177	+2.321	.010	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.587	+2.827	.048	.035	3	2
UCEC	EGFR_pY1068 →	-0.296	-3.000	.018	.036	3	1
UCEC	INPP4B →	-0.387	-3.169	.017	.018	3	1
UCEC	Ku80 →	+0.242	+2.335	.041	.020	3	1
UCEC	mTOR_pS2448 →	-0.210	-2.321	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Stathmin by SGTA expression — UCEC

Explore this box plot interactively →