SGTA

Across TCGA cell cohorts, SGTA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,460 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SGTA-associated GO terms across cancer lineages are Regulation of anaphase-promoting complex-dependent catabolic process, Negative regulation of protein localization to chromatin, and Subtelomeric heterochromatin formation. Each is linked with SGTA in more than 16 cancer types. Because this analysis shows association rather than direction, both SGTA-to-partner and partner-to-SGTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of anaphase-promoting complex-dependent catabolic process grouped by SGTA-low versus SGTA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SGTA→partner) and Y-score (partner→SGTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.210	+0.705	.008	.001	3	17
PANCREAS	Negative regulation of protein localization to chromatin →	+0.161	+0.731	<.001	<.001	3	16
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.137	+0.846	<.001	<.001	3	16
STOMACH	Regulation of protein localization to chromatin →	+0.142	+0.820	<.001	<.001	3	15
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.189	+0.564	.001	.005	3	15
UPPER_AERODIGESTIVE_TRACT	DNA replication-dependent chromatin assembly →	+0.131	+0.769	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,460 associations by consensus.

Regulation of anaphase-promoting complex-dependent catabolic process by SGTA expression — BONE

Explore this box plot interactively →