SGSM3

Across TCGA pan-cancer cohorts, SGSM3 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SGSM3 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SGSM3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SGSM3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where SGSM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.543	0.287	.001	64	view →
UCEC	DFS	Median	All	0.963	0.844	.004	24	view →
CCRCC	DFS	Median	IV	0.135	0.861	.002	15	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
LSCC	DFS	Median	II,III,IV	0.824	0.999	.027	3	view →
LUAD	DFS	Median	All	0.813	0.989	.008	3	view →
HNSC	OS	Median	III,IV	0.924	0.810	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SGSM3–PDAC (DFS)

Open the PDAC breakdown →