SGSM3

Across TCGA patient cohorts, SGSM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible SGSM3-associated GO terms across cancer lineages are Positive regulation of sphingolipid biosynthetic process, Base-excision repair, gap-filling, and Depyrimidination. Each is linked with SGSM3 in more than 24 cancer types. Because this analysis shows association rather than direction, both SGSM3-to-partner and partner-to-SGSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sphingolipid biosynthetic process grouped by SGSM3-low versus SGSM3-high in LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM3→partner) and Y-score (partner→SGSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Positive regulation of sphingolipid biosynthetic process →	+0.066	+0.610	<.001	<.001	3	25
KIRC	Base-excision repair, gap-filling →	+0.049	+0.511	<.001	<.001	3	22
KIRC	Depyrimidination →	+0.053	+0.455	<.001	<.001	3	21
LUAD	Cardiolipin biosynthetic process →	+0.034	+0.492	<.001	<.001	3	21
OV	Autophagosome-lysosome fusion →	+0.047	+0.438	<.001	<.001	3	20
OV	COPI-coated vesicle budding →	+0.045	+0.425	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

Positive regulation of sphingolipid biosynthetic process by SGSM3 expression — LUAD

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