SGSM3

Across TCGA patient cohorts, SGSM3 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGSM3-associated genes across cancer lineages are mTOR_pS2448, ATM, and EGFR_pY1068. Each is linked with SGSM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGSM3-to-partner and partner-to-SGSM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SGSM3-low versus SGSM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM3→partner) and Y-score (partner→SGSM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.172	-3.794	<.001	<.001	3	3
UCEC	ATM →	-0.622	-2.986	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.252	-1.736	.003	.007	3	2
COAD	eIF4E →	+0.226	+3.025	.014	.019	3	2
UCEC	MSH6 →	-0.367	-2.459	.001	.018	3	2
UCEC	Notch1 →	+0.135	+2.013	.005	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

mTOR_pS2448 by SGSM3 expression — UCEC

Explore this box plot interactively →