SGSM1

Across TCGA patient cohorts, SGSM1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGSM1-associated genes across cancer lineages are eIF4E, ERK2, and ATM. Each is linked with SGSM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGSM1-to-partner and partner-to-SGSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SGSM1-low versus SGSM1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM1→partner) and Y-score (partner→SGSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.234	+2.828	.005	.033	3	3
UCEC	ERK2 →	+0.185	+2.247	.001	.001	3	3
UCEC	ATM →	-0.522	-1.857	<.001	<.001	3	3
STAD	Caveolin-1 →	-0.895	-3.321	.011	.010	3	2
SKCM	p38-MAPK →	-0.147	-1.568	.003	.014	3	2
SKCM	p53 →	+0.179	+1.260	.001	.025	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eIF4E by SGSM1 expression — STAD

Explore this box plot interactively →