SGSM1

Across TCGA cell cohorts, SGSM1 mutation is significantly associated with the RNA expression of many other genes, with 691 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SGSM1-associated genes across cancer lineages are MED31, TRAPPC13, and OSCP1. Each is linked with SGSM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGSM1-to-partner and partner-to-SGSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED31 grouped by SGSM1-low versus SGSM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSM1→partner) and Y-score (partner→SGSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MED31 →	+0.675	+2.743	<.001	.001	3	2
LARGE_INTESTINE	TRAPPC13 →	+0.402	+3.321	.006	.003	3	2
LARGE_INTESTINE	OSCP1 →	+0.611	+2.043	.004	.008	3	2
LARGE_INTESTINE	LARP1B →	+0.764	+3.087	<.001	.006	3	2
LARGE_INTESTINE	SCD5 →	+1.105	+3.169	.006	.009	3	2
LARGE_INTESTINE	TRIM7 →	+1.781	+2.743	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 691 associations by consensus.

MED31 by SGSM1 expression — LARGE_INTESTINE

Explore this box plot interactively →