SGSH

Across TCGA patient cohorts, SGSH mutation is significantly associated with the RNA expression of many other genes, with 1,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGSH-associated genes across cancer lineages are RNA5SP113, MIR548H4, and MIR7702. Each is linked with SGSH in more than 2 cancer types. Because this analysis shows association rather than direction, both SGSH-to-partner and partner-to-SGSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP113 grouped by SGSH-low versus SGSH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSH→partner) and Y-score (partner→SGSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP113 →	+0.598	+3.226	<.001	.005	3	3
BRCA	MIR548H4 →	+0.257	+8.055	<.001	.007	3	2
UCEC	MIR7702 →	+0.245	+4.360	<.001	.004	3	2
LUSC	RNU6-383P →	+0.429	+5.309	<.001	.003	3	2
HNSC	OR7E101P →	+0.336	+4.624	<.001	.004	3	2
HNSC	FAM242D →	+0.050	+4.655	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,149 associations by consensus.

RNA5SP113 by SGSH expression — UCEC

Explore this box plot interactively →