SGSH

Across TCGA patient cohorts, SGSH mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGSH-associated genes across cancer lineages are p90 RSK, PCNA, and Cyclin-B1. Each is linked with SGSH in more than 1 cancer types. Because this analysis shows association rather than direction, both SGSH-to-partner and partner-to-SGSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by SGSH-low versus SGSH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSH→partner) and Y-score (partner→SGSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.232	+3.335	.020	.005	3	1
UCEC	PCNA →	+0.286	+2.999	.011	.035	3	1
UCEC	Cyclin-B1 →	+0.855	+3.321	.003	.010	2	1
UCEC	FoxM1 →	+0.331	+3.321	.014	.010	1	1
UCEC	p62 Lck ligand →	+0.563	+3.321	<.001	.010	1	1
UCEC	eEF2K →	+0.457	+2.183	.012	.035	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

p90 RSK by SGSH expression — UCEC

Explore this box plot interactively →