SGSH

Across TCGA cell cohorts, SGSH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,599 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SGSH-associated GO terms across cancer lineages are Heparan sulfate proteoglycan catabolic process, Glycosaminoglycan catabolic process, and Regulation of pattern recognition receptor signaling pathway. Each is linked with SGSH in more than 11 cancer types. Because this analysis shows association rather than direction, both SGSH-to-partner and partner-to-SGSH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heparan sulfate proteoglycan catabolic process grouped by SGSH-low versus SGSH-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SGSH→partner) and Y-score (partner→SGSH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Heparan sulfate proteoglycan catabolic process →	+0.192	+1.088	<.001	<.001	3	12
BONE	Glycosaminoglycan catabolic process →	+0.252	+1.581	.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of pattern recognition receptor signaling pathway →	+0.070	+1.326	<.001	.001	3	11
BONE	Glycoprotein catabolic process →	+0.133	+1.056	.001	<.001	3	11
SKIN	Lysosome organization →	+0.086	+1.634	<.001	<.001	3	11
SKIN	Lytic vacuole organization →	+0.086	+1.634	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,599 associations by consensus.

Heparan sulfate proteoglycan catabolic process by SGSH expression — BONE

Explore this box plot interactively →