SGPP2

Across TCGA patient cohorts, SGPP2 mutation is significantly associated with the RNA expression of many other genes, with 1,365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGPP2-associated genes across cancer lineages are MIR3137, FDX1P2, and RNA5SP488. Each is linked with SGPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGPP2-to-partner and partner-to-SGPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3137 grouped by SGPP2-low versus SGPP2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPP2→partner) and Y-score (partner→SGPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3137 →	+0.357	+3.838	.002	.006	3	2
UCEC	FDX1P2 →	+0.125	+2.953	.003	.001	3	2
BLCA	RNA5SP488 →	+0.403	+4.948	<.001	<.001	3	2
SKCM	OR5F1 →	+0.056	+5.212	<.001	.002	3	2
COAD	MIR1283-1 →	+0.726	+7.741	<.001	.009	3	2
COAD	MIR4535 →	+0.551	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,365 associations by consensus.

MIR3137 by SGPP2 expression — SKCM

Explore this box plot interactively →