SGPP2

Across TCGA patient cohorts, SGPP2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGPP2-associated genes across cancer lineages are JNK_pT183_Y185, VHL, and MSH6. Each is linked with SGPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SGPP2-to-partner and partner-to-SGPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SGPP2-low versus SGPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPP2→partner) and Y-score (partner→SGPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.243	-3.156	.008	.020	3	1
UCEC	VHL →	-0.989	-3.169	.007	.020	3	1
UCEC	MSH6 →	-0.769	-2.990	<.001	.036	2	1
UCEC	p70-S6K →	+0.259	+3.196	.014	.010	2	1
UCEC	PDCD4 →	-0.871	-3.169	<.001	.020	2	1
UCEC	MEK1 →	+0.699	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK_pT183_Y185 by SGPP2 expression — UCEC

Explore this box plot interactively →