SGPP1

Across TCGA pan-cancer cohorts, SGPP1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SGPP1 data layer compared with 20 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SGPP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SGPP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRC, LUSC, and CESC are the cancer types where SGPP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.054	0.881	<.001	48	view →
LUSC	OS	Median	All	0.225	0.660	.019	9	view →
CESC	DFS	Median	IV	0.053	0.529	<.001	6	view →
ESCA	DFS	Median	II,III,IV	0.107	0.522	.012	6	view →
UCEC	DFS	Median	All	0.953	0.619	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SGPP1–KIRC (OS)

Open the KIRC breakdown →