SGPP1

Across TCGA pan-cancer cohorts, SGPP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SGPP1 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SGPP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SGPP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where SGPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	0.851	0.511	.002	36	view →
LSCC	OS	Quartile	II,III,IV	0.492	0.941	<.001	21	view →
PDAC	DFS	Quartile	All	0.287	0.642	.001	13	view →
UCEC	DFS	Quartile	All	0.765	0.959	.046	4	view →
GBM	DFS	Median	All	0.540	0.799	.023	3	view →
LUAD	DFS	Median	All	0.509	0.731	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SGPP1–HNSC (DFS)

Open the HNSC breakdown →