SGPP1

Across TCGA patient cohorts, SGPP1 mutation is significantly associated with the RNA expression of many other genes, with 2,348 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SGPP1-associated genes across cancer lineages are MIR4659A, MIR4797, and RN7SL134P. Each is linked with SGPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SGPP1-to-partner and partner-to-SGPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4659A grouped by SGPP1-low versus SGPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SGPP1→partner) and Y-score (partner→SGPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4659A →	+0.365	+2.226	<.001	.001	3	3
READ	MIR4797 →	+1.014	+5.469	<.001	<.001	3	3
UCEC	RN7SL134P →	+0.099	+2.097	.002	.005	3	2
UCEC	TMPOP1 →	+0.104	+1.774	<.001	.004	3	2
COAD	SNRPGP8 →	+0.286	+5.721	<.001	.001	3	2
LUSC	RN7SL564P →	+0.304	+4.211	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,348 associations by consensus.

MIR4659A by SGPP1 expression — UCEC

Explore this box plot interactively →